Front Cover: An Extremely Stable Interprotein Tetrahedral Hg(Cys) ₄ Core Forms in the Zinc Hook Domain of Rad50 Protein at Physiological pH (Chem. Eur. J. 66/2022)

HgII interacting with a naturally ZnII-containing Rad50 protein interface yields HgS4 species, the strongest metal–protein interaction known to date. It also introduces novel manifestation of mechanism prokaryotic and eukaryotic cells. Furthermore, substitution occurring ZnII possibly has an impact on quaternary structure assembly process, thus disrupting DNA-repair mechanisms that engage Mre11–Rad50 complex. More information can be found in Research Article by A. Krężel co-workers. (DOI: 10.1002/chem.202202738).